Course Content

This course will cover the statistical background to the mixed model and will emphasise its practical application in medical data with particular reference to clinical trials. All analyses will be illustrated using SAS and lectures will be combined with practical sessions in order to reinforce concepts. Topics covered include:

Day 1

• General concepts and underlying statistical theory
• Use and interpretation of PROC MIXED
• Multi-centre trials and meta-analysis
• Consideration of issues such as biased standard errors, significance testing and negative variance components.

Day 2

• Repeated measures trials
• Random coefficients models
• Crossover trials
• More complex trial designs
• Introduction to Bayesian methods and PROC MCMC

Day 3

• Generalised linear mixed models
• Mixed models for ordinal data
• Use of PROC GLIMMIX, PROC GENMOD and PROC MCMC

Note the practical sessions will focus on constructing models and interpreting results from PROC MIXED output and are therefore not "hands on".

Registration will be at 9am on Day 1 and the course will close at 3pm on Day 3.